FROM THE KITCHEN TO THE HOSPITAL, WHERE, HOW AND WHY A SPICE HAS BECOME ONE OF THE MOST PROMISING AND STUDIED ASSETS IN THE WORLD!
Curcuma is a perennial rhizomatous herbaceous plant belonging to the Zingiberaceae family. It comes from South East Asia. In India, this sacred spice, obtained from crushed rhizomes, has been used for its many virtues for more than 4.000 years.
Its active ingredient is curcumin or diferuloylmethane, orange yellow pigment, which gives it its characteristic colour. Curcuma goes into the composition of curry.
Many researchers are working on its activities and how it works. At the beginning of May 2017, in the temple of science «Pubmed», the word curcuma is cited in 2893 articles and «Curcumin» 10166 times.
- The properties of curcumin are quite numerous. It has a powerful anti-inflammatory potential in all tissues throughout the body (PAN & al, 2000).
In fact, it blocks the NF-kB which remains anchored in cytoplasm and can no longer perform its transcription function in the cellular nucleus. In this way, it inhibits the formation of pro-inflammatory genetic products regulated by NF-kB such as PGE2, COX-2, TNF, 5-LOX, IL-1, IL6-, IL-8 and no less than 24 other pro-inflammatory factors (AGGARWAL & al, 2009; SGORLON & al, 2016).
It is also an effective antioxidant; it increases the activity of glutathione peroxidase, catalase and glutathione reductase. It inhibits lipid peroxidation and neutralizes oxygen produced by macrophages (RAMSEWAK & al, 2000; SOMPARN & al, 2007).
- Large epidemiological studies show that human populations consuming large amounts of curcumin have less breast, prostate, lung and colon cancer (CHAUHAN, 2002; LOPEZ-LAZARO & al, 2008).
Its anti-cancerous properties are taken very seriously. Curcumin alone or in combination with chemotherapy stabilizes patients with pancreatic or colorectal cancer. Curcumin increases the therapeutic effects of radiation therapy and chemotherapy by making cancer cells more sensitive to treatments. It also reduces the side effects associated with these treatments (SHARMA & al, 2001; DHILLON & al, 2008; EPELBAUM & al, 2010; PADHYE & al, 2010).
- It is a very safe asset because a daily intake of 12 g of curcumin for 3 months has no side effects.
- Many studies (GOEL & al, 2008) show that curcumin is an antiproliferative, anti-angiogenesis agent. Pre-cancerous lesions have decreased in at-risk patients (CHENG & al, 2001; REUTER & al, 2008).
- It also has hepatoprotective and nephroprotective activities. It reduces the incidence of thrombosis and myocardial infarction.
It also has hypoglycaemic properties (NISHIYAMA & al, 2005; LIU & al, 2006).
- Its low water solubility and poor bioavailability in its native form have prompted researchers to develop super curcumins: complex phospholipid micellar systems that improve efficiency (ANAND & al, 2008).
Curcumin still has many secrets to share. Do not deprive yourself of these numerous beneficial effects!
On the road to cure-cumin with The Spice of Life!