PROPERTIES

• Neuroprotective:

Ginkgo improves orientation, language, social behaviour and concentration. It relieves depression and anxiety (DI RENZO, 2000 ; VAN DONGEN & al, 2000 ; KURIBARA & al, 2003 ; NOOSHINFAR & al, 2007 ; KALKUNTE & al, 2007 ;; WILLIAMSON & al, 2008 ; ROJAS & al, 2011), and is a potent neuroprotective agent (AHLEMEYER & KRIEGLSTEIN, 2003 ; NOOSHINFAR & al, 2008 ; ROJAS & al, 2011).

Its neuroprotective effects are apparent in hypoxia if neurons come into contact with glutamate, nitric oxide (NO) or amyloid-beta plaques (AHLEMEYER & KRIEGLSTEIN, 2003). It reduces neuronal apoptosis in cases of ischaemia and contact with free radicals (NI & al, 1996 ; AHLEMEYER & al, 1999 ; XIN & al, 2000), and blocks the effect of drugs that induce amnesia (MK-801, scopolamine) (TADANO & al, 1998 ; NOOSHINFAR & al, 2008).Ginkgo inhibits the breakdown of dopamine, serotonin and norepinephrine in the synapses. It boosts the action of acetylcholine, which is abnormally low in patients with senile dementia (KRISTOFIKOVA & al, 1992 ; DI RENZO, 2000 ; ROJAS & al, 2011).

During forced swim tests (a rodent experimental model designed to assess responses to stress), it increases dopamine and serotonin levels, demonstrating its antidepressant effect (ROJAS & al, 2011). Ginkgo is involved in the glutamatergic system, which plays a pivotal role in memory. It acts on CREB (a transcription protein present in all cells), which enhances neuron regeneration, survival and rehabilitation. CREB increases the synthesis of many neuroprotective proteins, such as Bcl-2 and BDNF (brain-derived neurotrophic factor). BDNF promotes the growth and differentiation of new neurons and synapses involved in long-term memory.

It also stimulates and controls neurogenesis (ZHANG & al, 2011). Following neuronal injury, it improves plasticity and restoration of normal brain function in cats (EZ-ZAHER & LACOUR, 1989 ; LACOUR & al, 1991).

• Antioxidant:

Ginkgo is a powerful antioxidant that neutralises free radicals and prevents lipid peroxidation. It improves membrane fluidity (Le Bars et al., 1997) and increases levels of superoxide dismutase (SOD) and catalase (BRIDI & al, 2001).

• Anti-platelet aggregation and vasodilator effects:

Ginkgo is a platelet-activating factor (PAF) antagonist (SMITH & al, 1996). PAFs rise in the event of injury and inflammation, and increase the severity of the injury (SOGOS & al, 1990).

Ginkgo also increases blood flow around the body (ZHU & al, 1997), causes vascular dilation and lowers blood viscosity (SOHOLM & al, 1998 ; BIRKS & al, 2002).
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So to keep your brain and your pets in good shape, enjoy the exceptional health benefits of ginkgo!